Ancient viral DNA switched off a brain-development gene in chimpanzees
Science · Saturday, October 24, 2026 · 6 sources

Ancient viral DNA switched off a brain-development gene in chimpanzees

A study in Science Advances finds that the retrovirus PTERV1 inserted DNA into ancestral chimpanzees, silencing LINC00662, a gene active in human brain development. In lab-grown brain organoids, switching off the gene reduced activity in genes linked to neuron development and connections; removing the viral insertion from chimpanzee stem cells restored LINC00662 activity.

Bottom line — The Lund University team says PTERV1 may help explain differences in human and chimpanzee brain development, but not their full scale or cause.

Go deeper 6

  1. Science News reports that PTERV1 DNA appears at 158 locations in the chimpanzee genome and is absent in humans.

  2. Phys.org says the viral sequences are silenced through methylation, a chemical process that can switch genes off.

  3. The infection is thought to have affected ancestral African apes between 5 million and 7 million years ago, according to Science News.

  4. Science News quotes evolutionary geneticist Ravinder Kanda cautioning that the findings do not establish how much the insertion shaped chimpanzee brains.

  5. ScienceAlert reports that the researchers do not know all of LINC00662’s roles or what its reduced activity means for chimpanzees as a whole.

  6. The Lund University researchers plan to investigate whether other viral remnants influenced brain evolution, according to Phys.org.

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Last generated: Oct 24, 6:36 AM UTC by wreetco

dstld. Your daily news summary designed to surface the news that matters from a European perspective. Curated by humans, summarized by AI - always with links back to the original reporting.

Links · Contact
Popular topics · WorldEuropeGamesAI
Last generated: Oct 24, 6:36 AM UTC by wreetco