Phage enzymes trigger bacteria’s self-destruct immune response
Researchers found that a protease produced by some bacteriophages cuts a bacterial sensor protein, activating the CBASS immune system. The infected bacterium then kills itself, which can stop the virus spreading to neighbouring cells, according to ScienceDaily and Genetic Engineering & Biotechnology News.
Bottom line — The Science study may help guide phage therapies, while offering clues to an immune pathway shared with humans.
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Genetic Engineering & Biotechnology News reports that CBASS detects the effects of a viral protein on a bacterial protein, rather than sensing viral genetic material directly.
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ScienceDaily says the bacterial response is a last resort: activation kills the infected cell.
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Sam Hobbs of University of Utah Health told ScienceDaily that CBASS is related to an immune pathway found in people.
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The research, titled “Phage proteases activate CBASS antiphage immunity”, was published in Science.