Bat DNA reveals longevity linked to immune function and cell death strategy
Researchers at UC Berkeley and Penn State analyzed genomes of long-lived Myotis bats, finding that their longevity is tied to immune genes that fight cancer and a strategy of killing damaged cells rather than repairing them. The study suggests that understanding bat immunity could inform human aging and disease prevention.
Bottom line — The study identifies specific genetic overlaps between bat longevity and viral interaction genes, pointing to immune system evolution as a key to extended lifespan.
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- The longest-lived bat, the little brown bat, prioritizes cell death over DNA repair when exposed to toxins, per the study published in Nature.
- Bats have unusually high immune activity, allowing them to host many viruses without getting sick, according to researchers.
- There is significant overlap between genes associated with bat lifespan and those involved in bat-virus interactions, said lead author Juan Manuel Vazquez.
- The mismatch between bat and human immune defenses may explain why bat-borne viruses are dangerous to humans, Vazquez argued.
- The study analyzed eight Myotis genomes, including Brandt's myotis which can live up to 50 years, per the paper.